I know that this really isn’t the type of thing that is asked about frequently, but I gotta ask. When someone smokes marijuana, they get the much-fabled “munchies.” I know that this occurs, I am just at a loss as to why it does occur. What is the physiological reasons for this to occur?
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Last time the subject of the munchies came up, in 1977–I’ve been writing this column longer than a lot of you sumbitches have been alive–all I could tell you was that scientists had ruled out dope-induced fluctuations in blood sugar as a cause. Since then, I’m pleased to inform you, great strides have been made. As it turns out, far from being a mere curiosity, the munchies provide a clue to the workings of one of the body’s primary methods of hunger regulation, the endogenous cannabinoid system.
Your body, it seems, contains specialized proteins called cannabinoid receptors. (Broadly speaking, receptors react to certain stimuli and produce certain results.) The best-known cannabinoid is delta 9-tetrahydrocannabinol or THC, the principal psychoactive ingredient of weed (aka cannabis). Far more important from the body’s standpoint, however, are the endogenous (i.e., internally synthesized) cannabinoids, endocannabinoids for short, which work like neurotransmitters and are produced as part of the built-in apparatus by which peripheral parts of the body inform the brain that it’s lunchtime. Endocannabinoids and cannabinoid receptors are abundant in the hypothalamus, the region of the brain that plays a pivotal role in appetite regulation. In 1992 researchers identified the first endocannabinoid and named it anandamide, from the Sanskrit ananda, meaning inner bliss. In other words, when you smoke dope, you’re replicating (albeit with much greater intensity) an effect the body produces naturally for itself.
